There are an abundance of tools at FantasyLabs to use for your NFL DFS lineups each week. Our most popular tools are our NFL Player Models, which house our NFL DFS projections from Sean Koerner.
You can use these projections in our models with our Lineup Builder to hand-build your lineups or use our Lineup Optimizer to effortlessly create up to 150 lineups for your NFL DFS tournaments.
In this article, we will go position by position, highlighting my favorite plays for both cash games and single-entry/three-max GPP contests. These plays are also viable in large field tournaments but do not focus on ownership percentages.
NFL DFS Cash Game + Single-Entry GPP Locks
NFL DFS Quarterback Picks
Patrick Mahomes ($7,900 DraftKings, $8,500 FanDuel) Kansas City Chiefs vs. Jacksonville Jaguars
I doubt people would have believed you if you said before the season you’d be debating Patrick Mahomes vs. Justin Fields in DraftKings cash in Week 10, with the way the fantasy community was so down on the Bears signal caller, but here we are.
Mahomes remains the much safer option, but you have to pay for it. He is, however, coming off his best performance of the season against the Titans, where he posted 38.1 DK points. Mahomes threw 68 times last week as Kansas City trailed for the majority of the second half, and while that’s unlikely to happen, it underlines how high Mahomes’ ceiling is when the Chiefs are in competitive games.
While the path of least resistance against the Jaguars remains on the ground, the Chiefs simply cannot run the ball effectively — and just to make matters worse, Jerick McKinnon is now listed questionable — setting it up to yet again be the Mahomes/Kelce show. The Chiefs have the highest implied team total on the slate, which now sits at a whopping 30.25 points.
Simply put, they are going to score, and playing Mahomes is the most optimal way to capture those points.
Justin Fields ($6,500 DraftKings, 8,300 FanDuel) Chicago Bears vs. Detroit Lions
Man, if you faded Fields last week, you got the blade. The question is, did DraftKings price him high enough in this home tilt with the Lions? He’s coming off an NFL record (for a QB) 178 yards rushing while accounting for four total touchdowns and 45.72 DraftKings points.
There is no question that Mahomes is the safer option when you factor in the state of the Chiefs’ running game and their team total. However, you can save $1,400 by dropping to Fields. His dominant performance against Miami also marked the third straight game in which he’s gone over 24 DraftKings points.
If you’re sorting by points per dollar, Fields is the best QB play on the slate, despite his raw median projection being four points less than Mahomes.
NFL DFS Running Back Picks
Alvin Kamara ($7,400 DraftKings, $8,600 FanDuel) New Orleans Saints @ Pittsburgh Steelers
We can simply throw last week’s game against the Ravens out the window, as the Saints simply couldn’t get anything going on offense. This week will be different, as the Steelers have allowed the ninth most points per game in the NFL and rank dead last in yards per pass attempt allowed. With Michael Thomas likely to miss the rest of the season, and Andy Dalton under center yet again, Kamara will remain the focal point of this offense.
Prior to last week, Kamara had caught six or more passes in each of his previous four games. His pass game role is too big to fade at just $7,400 in this spot. He will likely be chalky in all formats, but eating running back chalk is fine because of the projectable volume.
I am expecting a strong bounce-back game from Kamara here.
Dameon Pierce (6,300 DraftKings, $7,700 FanDuel) Houston Texans @ New York Giants
The Texans are god-awful, but they are absolutely dead set on giving Pierce the rock regardless of score or game script. Despite losing for the majority of the second half against the Eagles last week, Pierce racked up a whopping 27 carries, which he turned into a very efficient 139 yards.
Surprisingly, and for the first time this season, he was not targeted in the passing game. He had seen four or more targets in each of his previous four weeks, however, so we should expect him to go back to normal usage in that department this week.
When you look at DraftKings points allowed, the Giants are good against running backs, but that number is misleading due only to the fact that they’ve given up just six touchdowns to the position. They are extremely easy to run on and have allowed the third-highest yards per carry to opposing running backs through nine weeks.
Pierce is simply too cheap for the volume he’s getting, and if he finds his way into the end zone, it’s wheels up.
NFL DFS Wide Receiver Picks
Amon-Ra St. Brown ($6,900 DraftKings, $6,900 FanDuel) Detroit Lions @ Chicago Bears
The story remains the same for St. Brown this week against the Bears. T.J. Hockenson is now in Minnesota, while Josh Reynolds has been ruled out again. The only thing is now the matchup gets way cleaner going from the Packers to the Bears, who rank 30th in pass defense DVOA and 30th in yards per pass attempt.
St. Brown had been battling an ankle injury for the better part of the season but was not on the final injury report last week and should be even better this week being ever further removed from the injury. We have not seen him tap into his massive upside since Week 2 against the Commanders, but all the contextual factors are lining up for him to be a target hog this week against the Bears and is still priced under $7,000 on DraftKings.
Whether you sort by FantasyLabs projections or Establish The Run’s, ARSB is the second-rated points per dollar wide receiver on the slate.
Mack Hollins ($4,200 DraftKings, $5,500 FanDuel) Las Vegas Raiders vs. Indianapolis Colts
Hunter Renfrow was placed on injured reserve earlier this week, freeing up even more targets in this Raiders offense. With the Raiders already down Darren Waller, the only remaining healthy pass catchers outside of Davante Adams include Foster Moreau, Keelan Cole, and DJ Turner. Hollins had already been playing nearly every snap with everyone healthy, and now should take on an even more prominent role.
Earlier this season, when Renfrow was out, Hollins went 10/158/1 against the Titans en route to 32.96 DraftKings points. Obviously, we are not expecting him to repeat that performance, but he’s going to be on the field a ton and costs just $4,200, making him one of the best points-per-dollar plays on the entire slate.
NFL DFS Tight End Picks
Greg Dulcich ($3,400 DraftKings, $5,900 FanDuel) Denver Broncos @ Tennessee Titans
Dulcich has made an immediate impact since making his debut against the Chargers in Week 6. He’s topped 11 DraftKings points in all three of his games. Despite this production, he’s still only priced at $3,400 on DraftKings this week and is arguably the best tight end play on the slate when you factor in price.
The Titans have been dreadful against tight ends this season, allowing the seventh most DraftKings points to the position, including a 10/106 performance to Travis Kelce last week. Obviously, Dulcic is not Kelce, but we likely have not seen his ceiling yet, and he’s going to get more expensive as the season moves along.
Foster Moreau ($3,200 DraftKings, $5,200 FanDuel) Las Vegas Raiders vs. Indianapolis Colts
The same reasoning applied above to Mack Hollins can be used for Moreau again this week. The Raiders’ pass-catching corps is extremely beat up at the moment, and Moreau will be on the field nearly every play for just $3,200.
With Darren Waller missing the last three games, Moreau posted snap count totals of 57/59, 58/58, and 54/56, respectively. He has not been great in this stretch, but has gone over five DraftKings points in all three games and remains a threat to catch a touchdown.
He remains an elite punt play in all formats.
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